英文名：icg maleimide
icg-mal
cas：2143933-81-5
分子式: c51h56n4o6s
分子量: 853.09
外 观：绿色粉末
溶解度：二氯甲烷纯 度：95%+结构式：
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西安凯新生物科技有限公司是国内业peg供应商，可以提供不同分子量的peg衍生物，小分子peg的循环节可以做到1-36个，高分子peg分子量从1000-40000不等，可以修饰的基团有：氨基类，nhboc类，fmoc类，羧酸类，mal类，nhs类，叠氮类，dbco类，cy3/cy5/cy7类，thp类，苄基类，丙炔基类，溴代类，丙酸叔丁酯类，乙酸叔丁酯类，甲基类，磺酸酯类，巯基类，产品纯度高达98%以上，我公司凭借业的技术，诚信的经营和不断创 新的精神而发展壮大，在发展的同时不忘不断总结不断优化为客户的服务，视客户取得成功为己任，力求将的产品、优 质的服务奉献给我们的客户。
供应商：西安凯新生物科技有限公司
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icg is a tricarbocyanine-type dye with nir-absorbing properties (peak absorption around 800 nm) and emission maximum at 807 nm (10% v/vdmso/pbs). little absorption in the visible range accounts for the low autofluorescence, tissue absorbance, and scattering at nir wavelengths (700-900 nm).
the maleimide of the icg dye offers the opportunity to develop optimal conjugates. maleimide active group provides an efficient and convenient way to selectively link icg dye to sulfhydryl groups (free thiol, r-sh) on various substrates (antibodies[1], peptides, proteins, oligonucleotides, small molecule drugs etc.) at neutral (physiological) ph without any activation. maleimides have very low reactivity with amines, alcohols, and phenols (incl. tyrosine and histidine) and do not react with histidine and methionine thus providing very high labeling selectivity.
it has been reported that conjugation to some antibodies may cause decrease in fluorescence intensity of icg bound to antibody due to the formation of h-dimers4. however, fluorescence is restored after cell binding and internalization, which can be used to design an activatable nir fluorescent probe. fluorescence intensity of the unbound icg-antibody conjugate can be dramatically increased (up to 50-fold) by addition of sds and β-mercaptoethanol, which diminishes π- π stacking5.
icg nhs ester的nhs可以和蛋白、多肽或抗体上面的nh2发生反应链接到一起。
icg-maleimide的马来酰亚胺可以和蛋白、多肽、小分子或抗体上的sh巯基反应连接。
icg-amine的nh2可以和蛋白、多肽小分子上面的nhs反应连接起来。
icg和peg链接可在体内长循环。
近红外荧光染料near irdyes激发和发射波长和颜色图：
icg nhs ester的nhs可以和蛋白、多肽或抗体上面的nh2发生反应链接到一起。
icg-maleimide的马来酰亚胺可以和蛋白、多肽、小分子或抗体上的sh巯基反应连接。
icg-amine的nh2可以和蛋白、多肽小分子上面的nhs反应连接起来。
icg和peg链接可在体内长循环。
icg衍生物产品：
icg nhs ester
icg vinylsulfone
icg isothiocyanate
icg carboxlaic acid icg-cooh
icg-maleimide/icg-mal/cas:2143933-81-5/
icg amine icg-nh2
icg thiol icg-sh
icg dichlorotriazine
icg hydrazide icg-hz
icg alkyne icg-alk
icg avidin icg-avidin 功能化icg修饰亲和素
icg biotin icg-biotin
mpeg-icg
icg-peg-nh2
icg-peg-cooh
icg-peg-mal
icg-peg-nhs
icg-peg-n3 叠氮peg化修饰标记荧光染料