5-氮杂-2′-脱氧胞苷
5-氮杂-2′-脱氧胞苷
性质
related categories an-az,approved therapeutics/drug candidates,bioactive small molecule alphabetical index,eisai,fluorination ready pharma-developed compounds,
更多...
inchi key xaudjqyhkzqpeu-kvqbguixsa-n
assay ≥97%
solubility acetic acid: water (1:1): 50mg/ml
originator eisai
产品描述
包装
5, 10 mg in glass bottle
50 mg in glass insert
application
5-aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, dna and promoter region of p16 gene.[3][4][5][6]
biochem/physiol actions
5′-脱氧杂氮胞苷可引起dna去甲基化或半去甲基化。dna去甲基化可通过随着提高的核酸酶活性而“打开”染色质的结构来调控基因的表达。这种染色质结构的重塑可实现转录因子与启动子区域的结合、转录复合物的组装及基因表达。
features and benefits
该化合物是基因调控研究的特色产品。点击此处以了解更多的基因调控特色产品。
该化合物由eisai开发。
5-aza-2′-deoxycytidine is a dna-hypomethylating agent, which stimulates differentiation and apoptosis of leukemic cells.[1]it is a 2′-deoxycytidine analogue.[2]5-aza-2′-deoxycytidine is used to treat chronic myelomonocytic leukemia, refractory anemia, myelodysplastic syndrome and acute myeloid leukemia.