超分辨率三重原料药及相关物质triple api pharmaceutical and related substances using ultra resolution
conditions
column: ace excel 1.7 superc18
dimensions: 100 x 3.0 mm; 2 x 100 x 3.0 mm
(coupled); 3 x 100 x 3.0 mm (coupled)
part number: exl -1711-1003u
mobile phase: a: h2o
b: mecn
c: 200 mm ammonium formate ph 3.0
gradient:
time (mins)
100x3.0mm
200x3.0mm
300x3.0mm
%a
%b
%c
-
0.00
0.00
90
5
5
0.00
1.21
2.41
90
5
5
5.00
11.21
17.41
20
75
5
6.00
12.21
18.41
20
75
5
6.50
13.21
19.41
90
5
5
flow rate: 0.8 ml/min
temperature: 80 °c
detection: uv, 270 nm
analytes
1. 2-aminophenol
2. hydroquinone
3. theobromine
4. paracetamol
5. paraxanthine
6. theophylline
7. 4-hydroxybenzoic acid
8. caffeine
9. 2-acetamidophenol
10. 2-hydroxybenzoic acid
11. phenol
12. aspirin
13. 4-nitrophenol
14. 4-chloroacetanilide
15. 2-nitrophenol
16. acetylsalicylsalicylic acid
17. salsalate
dimensions
resolution
peak capacity
rs5,6
pc
100 x 3.0 mm
1.63
154
200 x 3.0 mm
2.10
228
300 x 3.0 mm
2.31
271