90plus纳米粒度仪应用案例
文献名：optimizationofβ-caroteneloadedsolidlipidnanoparticlespreparationusingahighshearhomogenizationtechnique
作者：michael d. triplett ii
摘要：usingstatisticalexperimentaldesignmethodologies,thesolidlipidnanoparticledesignspacewasfoundtobemorerobustthanpreviouslyshowninliterature.formulationandhighshearhomogenizationprocesseffectsonsolidlipidnanoparticlesizedistribution,stability,drugloading,anddrugreleasehavebeeninvestigated.experimentationindicatedstearicacidastheoptimallipid,sodiumtaurocholateastheoptimalcosurfactant,anoptimumlecithintosodiumtaurocholateratioof3:1,andaninverserelationshipbetweenmixingtimeandspeedandnanoparticlesizeandpolydispersity.havingdefinedthebasesolidlipidnanoparticlesystem,β-carotenewasincorporatedintostearicacidnanoparticlestoinvestigatetheeffectsofintroducingadrugintothebasesolidlipidnanoparticlesystem.thepresenceofβ-caroteneproducedasignificanteffectontheoptimalformulationandprocessconditions,butthedesignspacewasfoundtoberobustenoughtoaccommodatethedrug.β-caroteneentrapmentefficiencyaveraged40%.β-carotenewasretainedinthenanoparticlesfor1month.asdemonstratedherein,solidlipidnanoparticletechnologycanbesufficientlyrobustfromadesignstandpointtobecomecommerciallyviable.
关键词：solidlipidnanoparticle,lipophileandpoorly-solubledrugdelivery,highshearhomogenization,b-carotene,lipids,bilesalts,statisticalmethodology