mouseanti-tlr5
from:abcam
catalognumber:ab13876
quantitysize:50ul(dilutewithph7.40.01mpbsorantibodydiluent)
backgroud:thetolllikereceptor(tlr)familyinmammalcomprisesafamilyoftransmembraneproteinscharacterizedbymultiplecopiesofleucinerichrepeatsintheextracellulardomainandil1receptormotifinthecytoplasmicdomain.likeitscounterpartsindrosophila,tlrssignalthroughadaptormoleculesandcouldconstituteanimportantandunrecognizedcomponentofinnateimmunityinhumans.thetrlfamilyisaphylogeneticallyconservedmediatorofinnateimmunitythatisessentialformicrobialrecognition.tlrscharacterizedsofaractivatethemyd88/interleukin1receptor-associatedkinase(irak)signalingpathway.toll-likereceptor5(tlr5)expressionisupregulatedfollowingexposuretobacteriaortothetlr5agonist,flagellin.gram-negativebacteria,stimulatemonocyte/macrophagecellsinatlr5-specific,cd14-independentmanner.thetlr5receptorthusappearstobetheprincipalmeansbywhichtheinnateimmunesystemrecognizesflagellatedbacterialpathogens.
function:
participatesintheinnateimmuneresponsetomicrobialagents.mediatesdetectionofbacterialflagellins.actsviamyd88andtraf6,leadingtonf-kappa-bactivation,cytokinesecretionandtheinflammatoryresponse(bysimilarity).
specificity:anti-tlr5isamousemonoclonalantibody
specificfortlr5ofhuman,mouse
-useforwesternblotting,elisa,immunoprecipitationandimmunohistochemistry
proteingaffinitychromatographypurification,purity:>95%isotype:iggmolwt:95kdaapplication:
flow-cyt=1:50-200wb=1:100-500elisa=1:500-1000ip=1:20-100ihc-p=1:100-500ihc-f=1:100-500if=1:100-500optimaldilutions/concentrationsshouldbedeterminedbytheenduser..storage:storeat-20℃foroneyear.avoidrepeatedfreeze/thawcycles.thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20℃.whenreconstitutedinsterileph7.40.01mpbsordiluentofantibody,theantibodyisstableforatleastsixweeksat2-4℃
importantnote:thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.