rabbitanti-icam-1/cd54
catalognumber:hz67213quantitysize:0.1ml(dilutewithph7.40.01mpbsorantibodydiluent)
background:celladhesionmolecules(cams)areafamilyofcloselyrelatedcellsurfaceglycoproteinsinvolvedincell-cellinteractionsduringgrowthandarethought
toplayimportant,yetseparate,rolesinembryogenesisanddevelopment.theintracellularadhesionmolecule-1(icam-1),alsoreferredtoascd54,isanintegralmembraneproteinoftheimmunoglobulinsuperfamilyandrecognizestheβ2α1andβ2αmintegrins.icam-2functionsasaligandforlymphocytefunction-associatedantigen-1(lfa-1)andisinvolvedinleukocyteadhesion.icam-3ishighlyexpressedonthesurfaceofhumaneosinophils,andwhenboundtoligandmayinhibiteosinophilinflammatoryresponsesandsurvival.icam-4,alsoknownaslwglycoprotein,interactswiththeintegrinsαlβ2,αmβ2,α4β1,theαvfamilyandαiibβ3,andselectivebindingtodifferentintegrinsmayberelevanttothepathologyinanumberofredbloodcellassociateddiseases.lastly,icam-5,expressedonencephalicneurons,bindscd11a/cd18andthusmayactasanadhesionmoleculeforleukocytebindinginthecentralnervoussystem.
pecificity:
anti-icam-1/cd54isarabbitpolyclonalantibodyunconjugated specificforicam-1/cd54ofhuman,mouse,rat useforwesternblotting,elisa,immunoprecipitationandimmunohistochemistry proteingaffinitychromatographypurification,purity:>95% isotype:igg molwt:85-110kda.application:
westernblotting1:100-500 immunohistochemistry1:100-500 elisa1:500-1000 optimalworkingdilutionsmustbedeterminedbytheenduser.storage:storeat-20℃foroneyear.avoidrepeatedfreeze/thawcycles.thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20℃.whenreconstitutedinsterileph7.40.01mpbsordiluentofantibody,theantibodyisstableforatleastsixweeksat2-4℃
importantnote:thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.