feasibility and diagnostic accuracy of an electronic nose in children with asthma and cystic fibrosis
电子鼻诊断患者哮喘和囊性纤维化可行性和准确性研究
michiel a g e bannier, kim d g van de kant, quirijn jöbsis and edward dompeling
published 8 may 2019 • © 2019 iop publishing ltd
journal of breath research, volume 13, number 3
abstract
the measurement of volatile organic compounds (vocs) in exhaled breath is a promising tool for diagnosing and monitoring various lung diseases in children. gas chromatography mass spectrometry (gc-ms) analysis is a frequently used standard technique for vocs analysis. however, as gc-ms is an expensive and time-consuming technique, hand-held devices or electronic noses have been developed. recently, the aeonose was introduced as an easy-to-use hand-held enose capable of point-of-care testing. although first results using this enose in adults are promising, studies in children are lacking. we therefore performed a cross-sectional study in 55 children and adolescents ≥6 years of age (20 children with moderate to severe asthma, 13 children with cf, and 22 healthy controls). the feasibility of the aeonose was high (>98% successful measurements). the diagnostic accuracy was high for discriminating asthma from cf (area under the receiver operating characteristic curve [auc] 0.90 [95% confidence interval 0.78–1.00] sensitivity 89% [65%–98%], specificity 77% [46%–94%]), and for the distinction between cf and healthy controls (auc 0.87 [0.74–1.00], sensitivity 85% [54%–97%], specificity 77% [54%–91%]). however, the diagnostic accuracy for the discrimination between asthma and healthy controls was modest (auc 0.79 [0.63–0.94], sensitivity 74% [49%–90%], specificity 91% [69%–98%]). this is the first study to report test results of the aeonose in children and adolescents ≥6 years. this enose showed a high feasibility with modest to good diagnostic accuracies in asthma and cf. this study was registered at clinicaltrial.gov (nct ).
呼出气体中挥发性有机物(voc)的测定是诊断和监测儿童各种肺部疾病的一种有前沿工具。气相色谱-质谱(gc-ms)分析是voc分析常用的标准技术。然而，由于gc-ms是一种昂贵且耗时的技术，所以已经开发出手持设备或电子鼻。近，aeonose被介绍为一种易于使用的手持e-nose，能够进行护理点测试。虽然在成人中实验中使用的个结果是有希望的，但对儿童的研究却缺乏。因此，我们对55名年龄≥6岁的儿童和青少年(20名中度至重度哮喘儿童、13名cf儿童和22名健康对照者)进行了横断面研究。aeonose的可行性很高(>98%的成功测量)。对哮喘与cf(受试者操作特征曲线下面积[auc]0.90[95%置信区间0.78-1.00]敏感度89%[65%-98%]、特异性77%[46%-94%])以及对cf与健康对照者的区分(auc 0.87[0.74–1.00]，敏感性85%【54%–97%】，特异性77%【54%–91%】)。然而，哮喘与健康对照之间的鉴别诊断准确度不高(auc 0.79[0.63–0.94]、敏感度74%[49%–90%]、特异性91%[69%–98%]。这是*报道6岁以上儿童和青少年aeonose检测结果的研究。本研究在clinicaltrial.gov(nct )上进行了注册。