anti-gfr alpha 3抗体
form：abcam
catalog number : byk-11501r
quantity size : 0.1ml (1mg/ml,lyophilized or liquid.buffer=0.01m pbs,ph 7.4 with 10 mg/ml bsa and 0.1% sodium azide.reconstitute with 0.1ml sterile distilled water.)
anti-gfr alpha 3抗体background: glial cell line-derived neurotrophic factor (gdnf) and the related neurotrophic factor neurturin (ntn) are potent survival factors for central and peripheral neurons. gdnf is a glycosylated, disulfide-bonded homodimer that is distantly related to the tgf beta superfamily of growth factors. three receptors for these factors, gfr alpha-1 (also designated gdnfr-alpha, retl1 or trnr-1), gfr alpha-2 (also designated gdnfr-beta, retl2, ntnr-alpha or trnr-2) and gfr alpha-3 have been identified. the receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. both gfr alpha-1 and gfr alpha-2 have been shown to mediate the gdnf-dependent and ntn-dependent phosphorylation and activation of the tyrosine kinase ret. gfr alpha-3 is expressed only during development.
specificity :
anti- gfr alpha 3 is a rabbit polyclonal antibody unconjugated specific for gfr alpha 3 of human,mouse,rat,use for western blotting,elisa,immunoprecipitation and immunohistochemistryprotein g affinity chromatography purification, purity :>95%isotype: iggmol wt: 33kda
anti-gfr alpha 3抗体application :
western blotting=1:100-500 immunohistocry 1:100-500 elisa= 1:500-1000 ihc-p=1:100-500ihc-f=1:100-500optimal working dilutions must be determined by the end user.
storage: store at -20℃ for one year. avoid repeated freeze/thaw cycles. the lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. when reconstituted in sterile ph 7.4 0.01m pbs or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
anti-gfr alpha 3抗体important note: this product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.