文献名：polymer-surfactantnanoparticlesforsustainedreleaseofwater-solubledrugs
作者：maheshd.chavanpatil,1aymankhdair,1yogeshpatil,1hiteshhanda,2guangzhaomao,2jayanthpanyam1,3
1departmentofpharmaceuticalsciences,eugeneapplebaumcollegeofpharmacyandhealthsciences,waynestateuniversity,detroit,mi48201
2departmentofchemicalengineeringandmaterialsscience,collegeofengineering,waynestateuniversity,detroit,mi48202
3karmanoscancerinstitute,detroit,mi48201
摘要：poordrugencapsulationefficiencyandrapidreleaseoftheencapsulateddruglimittheuseofnanoparticlesinbiomedicalapplicationsinvolvingwater-solubledrugs.wehavedevelopedanovelpolymer-surfactantnanoparticleformulation,usingtheanionicsurfactantaerosolottm(aot)andpolysaccharidepolymeralginate,forsustainedreleaseofwater-solubledrugs.particlesizeofnanoparticles,asdeterminedbyatomicforcemicroscopyandtransmissionelectronmicroscopy,wasintherangeof40–70nm.weaklybasicmoleculeslikemethyleneblue,doxorubicin,rhodamine,verapamil,andclonidinecouldbeencapsulatedefficientlyinaot-alginatenanoparticles.invitroreleasestudieswithbasicdrugmoleculesindicatethatnanoparticlesreleased60–70%oftheencapsulateddrugover4weeks,withnearzero-orderreleaseduringthefirst15days.studieswithanionicdrugmoleculesdemonstratepoorerdrugencapsulationefficiencyandmorerapiddrugreleasethanthoseobservedwithbasicdrugs.furtherstudiesinvestigatingtheeffectofsodiumconcentrationinthereleasemediumandthechargeofthedrugsuggestthatcalcium-sodiumexchangebetweennanoparticlematrixandreleasemediumandelectrostaticinteractionbetweendrugandnanoparticlematrixareimportantdeterminantsofdrugrelease.inconclusion,wehaveformulatedanovelsurfactantpolymerdrugdeliverycarrierdemonstratingsustainedreleaseofwater-solubledrugs.
关键词：alginate;drugdelivery;controlledrelease;nanoparticles;polyelectrolytes;surfactants