bioxcell热销产品--invivoplus anti-mouse cd8α
产品描述：
bioxcell invivoplus anti-mouse cd8α克隆号yts 169.4单克隆抗体能与小鼠cd8α反应。cd8抗原是一种跨膜糖蛋白，作为t细胞受体的共受体。与tcr一样，cd8与抗原呈递细胞(apc)展示的i类mhc分子结合。cd8主要在细胞毒性t细胞表面表达，但也可在胸腺细胞、自然杀伤细胞和一些树突状细胞亚群中发现。cd8最常见的存在形式是由一个cd8α和一个cd8β链组成的异二聚体，然而，它也可以是由两个cd8α链组成的同二聚体。cd8α和cd8β链均与免疫球蛋白可变轻链具有显著同源性。每个cd8链的分子量约为34 kda。bioxcell invivoplus anti-mouse cd8α克隆号yts 169.4抗体在体内使用时显示出depleting活性。
产品详情：
产品名称
invivoplus anti-mouse cd8α
产品货号
bp0117
产品规格
5/25/50/100mg
反应种属
mouse
克隆号
yts 169.4
同种型
rat igg2b, κ
免疫原
cba mouse thymocytes
实验应用
in vivocd8+ t cell depletionwestern blot
产品形式
pbs, ph 7.0,contains no stabilizers or preservatives
纯度
>95%, determined by sds-page
聚合
<5%, determined by sec
无菌处理
0.2 µm filtration
纯化方式
protein g
rrid
ab_10950145
分子量
150 kda
小鼠病原检测
ectromelia/mousepox virus: negative
hantavirus: negative
k virus: negative
lactate dehydrogenase-elevating virus: negative
lymphocytic choriomeningitis virus: negative
mouse adenovirus: negative
mouse cytomegalovirus: negative
mouse hepatitis virus: negative
mouse minute virus: negative
mouse norovirus: negative
mouse parvovirus: negative
mouse rotavirus: negative
mycoplasma pulmonis: negative
pneumonia virus of mice: negative
polyoma virus: negative
reovirus screen: negative
sendai virus: negative
theiler’s murine encephalomyelitis: negative
保存条件
抗体原液保存在4°c，不能冷冻保存。
推荐同型对照
invivoplus rat igg2b isotype control, anti-keyhole limpet hemocyanin（货号bp0090）
推荐抗体稀释液
invivopure ph 7.0 dilution buffer（货号ip0070）
为什么选择invivoplus抗体？
invivoplus级别的产品内毒素含量更低，经过多种实验验证，更适合用于体内实验研究
该产品自上市已被多篇sci文献引用，品质有保证，以下是部分已发表的文献引用：
应用
文章
体内cd8+t细胞耗竭
(in vivo cd8+ t cell depletion)
1.vashist, n., et al. (2018). 'influenza-activated ilc1s contribute to antiviral immunity partially influenced by differential gitr expression' front immunol 9: 505.
2.triplett, t. a., et al. (2018). 'reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme' nat biotechnol 36(8): 758-764.
3.carmi, y., et al. (2015). 'allogeneic igg combined with dendritic cell stimuli induce antitumour t-cell immunity' nature 521(7550): 99-104.
4.burrack, k. s., et al. (2015). 'myeloid cell arg1 inhibits control of arthritogenic alphavirus infection by suppressing antiviral t cells' plos pathog 11(10): e1005191.
5.wensveen, f. m., et al. (2015). 'nk cells link obesity-induced adipose stress to inflammation and insulin resistance' nat immunol 16(4): 376-385.
6.li, z., et al. (2015). 'pre-treatment of allogeneic bone marrow recipients with the cxcr4 antagonist amd3100 transiently enhances hematopoietic chimerism without promoting donor-specific skin allograft tolerance' transpl immunol 33(2): 125-129.
更多产品详情请联系 bioxcell 中国授权代理——欣博盛生物