磷酸化雄激素受体抗体*
『别名』androgenreceptor(phosphos363);androgenreceptor(phospho-ser363);androgenreceptor(phosphoser363);p-androgenreceptor(ser363);andr_human;hysp1;ais;androgenreceptor(dihydrotestosteronereceptor;testicularfeminization;spinalandbulbarmuscularatrophy;kennedydisease);ar;dhtr;dihydrotestosteronereceptor;dihydrotestosteronereceptor;humara;nuclearreceptorsubfamily3groupcmember4;sbma;smax1;spinalandbulbarmuscularatrophy;tfm.
『浓度』1mg/1ml
『规格』0.1ml/100μg
『抗体来源』rabbit
『克隆类型』polyclonal
『交叉反应』human,mouse,rat,pig,cow,horse,rabbit
『产品类型』一抗磷酸化抗体
『研究领域』细胞生物免疫学发育生物学信号转导转录调节因子激酶和磷酸酶
『蛋白分子量』predictedmolecularweight:99kda
『性状』lyophilizedorliquid
『免疫原』klhconjugatedsynthesisedphosphopeptidederivedfromhumanandrogenreceptoraroundthephosphorylationsiteoftyr363
『亚型』igg
『纯化方法』affinitypurifiedbyproteina
『储存液』preservative:15mmsodiumazide,constituents:1%bsa,0.01mpbs,ph7.4
『产品应用』wb=1:100-500elisa=1:500-1000ihc-p=1:100-500ihc-f=1:100-500icc=1:100-500if=1:100-500
（石蜡切片需做抗原修复）
notyettestedinotherapplications.
optimaldilutions/concentrationsshouldbedeterminedbytheenduser.
『保存条件』storeat-20°cforoneyear.avoidrepeatedfreeze/thawcycles.thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20°c.whenreconstitutedinsterileph7.40.01mpbsordiluentofantibodytheantibodyisstableforatleasttwoweeksat2-4°c.
importantnotethisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.
『产品介绍』androgenreceptor(ar)belongstothesuper-familyofnuclearhormonereceptorsthatemploycomplexmolecularmechanismstoguidethedevelopmentandphysiologicalfunctionsoftheirtargettissues.inmammals,exposuretoandrogensearlyindevelopmentisessentialformasculinizationofthemalereproductivephenotype.androgenstimulationresultsincellproliferationinboththedevelopmentofprostateandmalignantprostate.datafromanimalandhumanstudiesindicatethatsexsteroidshaveimportantskeletaleffects.androgensclearlyenhancebonesize,likelythrougheffectsonperiostealboneformation.similarlytoothersteroidreceptors,arisaphosphoprotein,butthefunctionalsignificanceofthecovalentreceptormodificationbyphosphorylationhasremainedenigmatic.
function:steroidhormonereceptorsareligand-activatedtranscriptionfactorsthatregulateeukaryoticgeneexpressionandaffectcellularproliferationanddifferentiationintargettissues.transcriptionfactoractivityismodulatedbyboundcoactivatorandcorepressorproteins.transcriptionactivationisdown-regulatedbynr0b2.activated,butnotphosphorylated,byhipk3.
subunit:bindsdnaasahomodimer.partofaternarycomplexcontainingar,efcab6/djbpandpark7.interactswithhipk3andnr0b2inthepresenceofandrogen.theligandbindingdomaininteractswithkat7/hbo1inthepresenceofdihydrotestosterone.interactswithefcab6/djbp,pelp1,pqbp1,ranbp9,rbak,spdef,sra1,tgfb1i1,znf318andrreb1.interactswithzmiz1/zimp10andzmiz2/zmip7whichbothenhanceitstransactivationactivity.interactswithslc30a9andrad54l2/arip4.interactsviatheligand-bindingdomainwithlxxllandfxxlfmotifsfromncoa1,ncoa2,ncoa3,ncoa4andmagea11.thearn-terminalpoly-glnregionbindsranresultinginenhancementofar-mediatedtransactivation.ran-bindingdecreasesasthepoly-glnlengthincreases.interactswithhip1(viacoiledcoildomain).interacts(vialigand-bindingdomain)withtrim68.interactswithtnk2.interactswithusp26.interactswithrnf6.interacts(regulatedbyrnf6probablythroughpolyubiquitination)withrnf14;regulatesartranscriptionalactivity.interactswithprmt2andtrim24.interactswithgnb2l1/rack1.interactswithranbp10;thisinteractionenhancesdihydrotestosterone-inducedartranscriptionalactivity.interactswithprpf6inahormone-independentway;thisinteractionenhancesdihydrotestosterone-inducedartranscriptionalactivity.interactswithstk4/mst1.interactswithzipk/dapk3.interactswithlpxn.interactswithmak.partofacomplexcontainingar,makandncoa3.
subcellularlocation:nucleus.cytoplasm.predominantlycytoplasmicinunligandedformbuttranslocatestothenucleusuponligand-binding.canalsotranslocatetothenucleusinunligandedforminthepresenceofgnb2l1.
tissuespecificity:isoform2ismainlyexpressedinheartandskeletalmuscle.
post-translationalmodifications:sumoylatedonlys-386(major)andlys-520.ubiquitinated.deubiquitinatedbyusp26.'lys-6'and'lys-27'-linkedpolyubiquitinationbyrnf6modulatesartranscriptionalactivityandspecificity.
phosphorylatedinprostatecancercellsinresponsetoseveralgrowthfactorsincludingegf.phosphorylationisinducedbyc-srckinase(csk).tyr-534isoneofthemajorphosphorylationsitesandanincreaseinphosphorylationandsrckinaseactivityisassociatedwithprostatecancerprogression.phosphorylationbytnk2enhancesthedna-bindingandtranscriptionalactivityandmayberesponsibleforandrogen-independentprogressionofprostatecancer.
disease:defectsinararethecauseofandrogeninsensitivitysyndrome(ais)[mim:300068];previouslyknownastesticularfeminizationsyndrome(tfm).aisisanx-linkedrecessiveformofpseudohermaphroditismdueend-organresistancetoandrogen.affectedmaleshavefemaleexternalgenitalia,femalebreastdevelopment,blindvagina,absentuterusandfemaleadnexa,andabdominaloringuinaltestes,despiteanormal46,xykaryotype.
defectsinararethecauseofspinalandbulbarmuscularatrophyx-linkedtype1(smax1)[mim:313200];alsoknownaskennedydisease.smax1isanx-linkedrecessiveformofspinalmuscularatrophy.spinalmuscularatrophyreferstoagroupofneuromusculardisorderscharacterizedbydegenerationoftheanteriorhorncellsofthespinalcord,leadingtosymmetricalmuscleweaknessandatrophy.smax1occursonlyinmen.ageatonsetisusuallyinthethirdtofifthdecadeoflife,butearlierinvolvementhasbeenreported.itischaracterizedbyslowlyprogressivelimbandbulbarmuscleweaknesswithfasciculations,muscleatrophy,andgynecomastia.thedisorderisclinicallysimilartoclassicformsofautosomalspinalmuscularatrophy.note=causedbytrinucleotidecagrepeatexpansion.insmax1patientsthenumberofglnrangesfrom38to62.longerexpansionsresultinearlieronsetandmoresevereclinicalmanifestationsofthedisease.
note=defectsinarmayplayaroleinmetastaticprostatecancer.themutatedreceptorstimulatesprostategrowthandmetastasesdevelopmentdespiteofandrogenablation.thistreatmentcanreduceprimaryandmetastaticlesionsprobablybyinducingapoptosisoftumorcellswhentheyexpressthewild-typereceptor.
defectsinararethecauseofandrogeninsensitivitysyndromepartial(pais)[mim:312300];alsoknownasreifensteinsyndrome.paisischaracterizedbyhypospadias,hypogonadism,gynecomastia,genitalambiguity,normalxykaryotype,andapedigreepatternconsistentwithx-linkedrecessiveinheritance.somepatientspresentazoospermiaorsevereoligospermiawithoutotherclinicalmanifestations.
similarity:belongstothenuclearhormonereceptorfamily.
nr3subfamily.
contains1nuclearreceptordna-bindingdomain.
e-(hu)（03）-00367 人磷酯酶c(plc)elisa试剂盒 ，英文名： phospholipasec，plcelisakit ，规格： 96t/48t
e-(hu)（03）-00368 人*蛋白酶(prss)elisa试剂盒 ，英文名： serineprotease，prsselisakit ，规格： 96t/48t
e-(hu)（03）-00369 人*(uk)elisa试剂盒 ，英文名： urokinase，ukelisakit ，规格： 96t/48t
e-(hu)（03）-00370 人弹性蛋白酶(elastase)elisa试剂盒 ，英文名： elastaseelisakit ，规格： 96t/48t
e-(hu)（03）-00371 人白细胞弹性蛋白酶(hle)elisa试剂盒 ，英文名： leukocyteexastase，hleelisakit ，规格： 96t/48t
e-(hu)（03）-00372 人α*(ams/amy)elisa试剂盒 ，英文名： α-amylase，ams/amyelisakit ，规格： 96t/48t
e-(hu)（03）-00373 人碱性磷酸酶(alp)elisa试剂盒 ，英文名： alkalinephosphatase，alpelisakit ，规格： 96t/48t
e-(hu)（03）-00374 人胶原酶ii(collagenaseii)elisa试剂盒 ，英文名： collagenasetypeiielisakit ，规格： 96t/48t
e-(hu)（03）-00375 人乙酰*酯酶(ache)elisa试剂盒 ，英文名： acetylcholinesterase，acheelisakit ，规格： 96t/48t
e-(hu)（03）-00376 人葡萄糖氧化酶(god)elisa试剂盒 ，英文名： glucoseoxidase，godelisakit ，规格： 96t/48t
e-(hu)（03）-00377 人透明质酸酶(haase)elisa试剂盒 ，英文名： hyaluronidase，haaseelisakit ，规格： 96t/48t
e-(hu)（03）-00378 人酸性磷酸酶(acp)elisa试剂盒 ，英文名： acidphosphatase，acpelisakit ，规格： 96t/48t
e-(hu)（03）-00379 人β葡萄糖醛酸苷酶(βgd)elisa试剂盒 ，英文名： β-glucuronidase，βgdelisakit ，规格： 96t/48t
e-(hu)（03）-00380 人β葡糖苷酶(β-glucosidase)elisa试剂盒 ，英文名： β-glucosidaseelisakit ，规格： 96t/48t
e-(hu)（03）-00381 人β内酰铵酶(β-lactamase)elisa试剂盒 ，英文名： β-lactamaseelisakit ，规格： 96t/48t
e-(hu)（03）-00382 人β甘露糖苷酶(βmanase)elisa试剂盒 ，英文名： αmannosidase，αmanaseelisakit ，规格： 96t/48t